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    常州市存仁生物工程有限公司

    產品 > PARP > PARP > UPF 1069
    產品名稱 : UPF 1069
    型號 : CR1750
    CAS : 1048371-03-4
    備注:所有產品僅用作科學研究,我們不為任何個人用途提供產品和服務 : 
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    產品詳細:

    Chemical Information

    M.Wt 279.29 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
    Formula C17H13NO3
    CAS No 1048371-03-4
    Solubility

    DMSO



    Biological Activity of UPF 1069

     

    UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM; ~27-fold selective against PARP1.
    IC50 Value:  0.3 μM
    Target: PARP2
    in vitro: In organotypic hippocampal slices, PARP-2 inhibition with UPF-1069 (0.01-1 micromolxL(-1)) caused a concentration-dependent exacerbation (up to 155%) of OGD-induced CA1 pyramidal cell death. Higher concentrations, acting on both PARP-1 and PARP-2, had no effect on OGD injury [1].
    in vivo: In organotypic hippocampal slices, PARP-2 inhibition with UPF-1069 (0.01-1 mM) causes a concentration-dependent exacerbation (up to 155%) of oxygen-glucose deprivation (OGD)-induced CA1 pyramidal cell death. Higher concentrations, acting on both PARP-1 and PARP-2, have no effect on OGD injury. In mouse mixed cortical cells exposed to OGD, UPF-1069 (1-10 mM) significantly reduces post-ischaemic damage.
    Clinical trial: N/A
     


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    注意事項:本產品為化學試劑,僅供科學研究和實驗室使用。


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