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GSK690693

Description of:GSK690693
GSK-690693 is an ATP-competitive pan-Akt kinase inhibitor (IC50 values are 2, 13 and 9 nM for Akt1, 2 and 3 respective...

Description of:MK-2206
MK-2206 is a potent allosteric Akt inhibitor with IC50 at 8 nm, 2 mM, 65 mM for Akt1, Akt2 and Akt3 respectively. 1 hr t...

Description of:AT7867
Administration of AT7867 (90 mg/kg p.o. or 20 mg/kg i.p.) to athymic mice implanted with the PTEN-deficient U87MG human g...

Description of:PHT-427
PHT-427 caused apoptosis and inhibited AKT phosphorylation. [1] PHT-427 itself (C-12 chain) bound with the highest affin...

Description of:Isobavachalcone
Isobavachalcone is a chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma.
Theo...

Description of:A-674563
A-674563 is a potent selective protein kinase B/Akt inhibitor with an IC50 of 14 nM. A-674563 also shows inhibitory act...

Description of:CCT128930
CCT128930 prevents AKT activity in vitro and in vivo and induces marked antitumor responses. CCT128930 showed si...

Description of:Palomid 529 (P529)
Palomid 529 (P529) inhibits the TORC1 and TORC2 complexes and shows both inhibition of Akt signaling an...

Description of:Perifosine
Perifosine is an Akt inhibitor. the antiproliferative properties of perifosine with an IC50 of 0.6–8.9 µM...

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